Histologic appearance of transmyocardial laser channels after 4 1/2 weeks.
نویسندگان
چکیده
Preliminary results of clinical studies suggest that transmyocardial laser revascularization is an effective treatment for patients with chronic angina that cannot be treated by other means. The mechanism of this effect remains controversial. We present autopsy results from a patient obtained 4 1/2 weeks after operation that show that the channels do not maintain patency. Further work is needed to determine the frequency of channel patency and its relation to clinical benefit.
منابع مشابه
Histologic analysis of transmyocardial channels: comparison of CO2 and holmium:YAG lasers.
BACKGROUND Transmyocardial laser revascularization using different lasers is being tested in the treatment of refractory angina. We conducted comparative analysis of the acute and chronic myocardial effects of these different lasers. METHODS Transmyocardial channels were made in normal dog hearts with either a holmium:yttrium-aluminum garnet or a CO2 laser. Channels were examined histological...
متن کاملPhysiology, histology, and 2-week morphology of acute transmyocardial channels made with a CO2 laser.
BACKGROUND Transmyocardial revascularization with a CO2 laser appears to improve symptoms in patients with refractory angina. However, it remains controversial as to whether blood flow through the channels is the mechanism of benefit, especially in the acute setting. METHODS AND RESULTS Three protocols were used to test whether blood flows through transmyocardial CO2 laser revascularization c...
متن کاملMechanism of TMR; the debate continues.
Clinical experience with transmyocardial laser revascularization has increased significantly over the last few years. Since several transmyocardial laser revascularization studies reported an apparent effect on the relief of angina and the FDA approved reimbursement of transmyocardial laser revascularization procedures in the USA, thousands of patients have been treated worldwide with different...
متن کاملEvidence of vascular growth associated with laser treatment of normal canine myocardium.
BACKGROUND Transmyocardial laser revascularization is a new therapy for patients with refractory angina. Although clinical studies suggest that transmyocardial laser revascularization decreases angina and may improve regional blood flow, the underlying mechanisms are not elucidated. We hypothesized that one mechanism may relate to stimulation of vascular growth in laser-treated regions. METHO...
متن کاملIs communication to endocardium necessary for angiogenesis in transmyocardial laser revascularization?
There is evidence of angiogenesis being induced after transmyocardial laser revascularization (TMLR), although the precise mechanism has not been fully elucidated. This study was designed to examine whether or not blood flow from the left ventricle through the channels is essential for angiogenesis following TMLR. Ten dogs underwent the creation of two types of laser channels in the left ventri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Annals of thoracic surgery
دوره 61 5 شماره
صفحات -
تاریخ انتشار 1996